Synthesis of 2,6-dimethyl-4-substituted pyridine-3,5-dicarbonitriles from beta-aminoacrylonitriles

Authors
Al-Omran, F El-Khair, AA
Citation
F. Al-omran et Aa. El-khair, Synthesis of 2,6-dimethyl-4-substituted pyridine-3,5-dicarbonitriles from beta-aminoacrylonitriles, I J CHEM B, 40(7), 2001, pp. 608-611
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
40
Issue
7
Year of publication
2001
Pages
608 - 611
Database
ISI
SICI code
0376-4699(200107)40:7<608:SO2PFB>2.0.ZU;2-Q
Abstract
beta -Aminoacrylonitrile reacts with aldehydes or cinnamaldehyde in the pre sence of HCl to give 2,6-dimethyl-4-substituted pyridine-3,5-dicarbo/nitrit es 2a-c. 2a-b on condensation with DMF/DMA afford 8a-b. Reaction of 2b with 4-N,N-dimethylaminobenzaldehyde yields 8c. The structures of the newly syn thesized compounds have been elucidated by elemental analyses and spectral data.