F. Al-omran et Aa. El-khair, Synthesis of 2,6-dimethyl-4-substituted pyridine-3,5-dicarbonitriles from beta-aminoacrylonitriles, I J CHEM B, 40(7), 2001, pp. 608-611
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
beta -Aminoacrylonitrile reacts with aldehydes or cinnamaldehyde in the pre
sence of HCl to give 2,6-dimethyl-4-substituted pyridine-3,5-dicarbo/nitrit
es 2a-c. 2a-b on condensation with DMF/DMA afford 8a-b. Reaction of 2b with
4-N,N-dimethylaminobenzaldehyde yields 8c. The structures of the newly syn
thesized compounds have been elucidated by elemental analyses and spectral
data.