Gynaecomastia in a male patient during stavudine and didanosine treatment for HIV infection

We report a case of gynaecomastia developed in a HIV-seropositive man, asso ciated with a severe lipodystrophy. We hypothesize the responsibility of st avudine and didanosine in the development of these 2 complications. If many reports suggest that the protease inhibitors may promote gynaecomastia, lo ng-term nucleoside analogue therapy may also cause this side effect.