Kg. Morgan et Ss. Gangopadhyay, Signal transduction in smooth muscle - Invited review: Cross-bridge regulation by thin filament-associated proteins, J APP PHYSL, 91(2), 2001, pp. 953-962
This minireview will cover current concepts on the identity and mechanistic
function of smooth muscle actin binding proteins that may regulate actin-m
yosin interactions. The potential roles of tropomyosin, caldesmon, calponin
, and SM22 will be discussed. The review, for purposes of brevity, will be
nonexhaustive but will give an overview of available information on the in
vitro biochemistry and potential in vivo function of these proteins. Preter
m labor is discussed as a possible example of where thin filament regulatio
n may be relevant. Considerable controversy surrounds the putative physiolo
gical significance of these proteins, and emphasis will be placed on the ne
ed for more experimental work to determine the degree to which tissue- and
species-specific effects have clouded the interpretation of functional data
.