Mh. Hyun et al., Note on the use of reciprocity of chiral recognition in designing liquid chromatographic chiral stationary phases, J CHROMAT A, 922(1-2), 2001, pp. 119-125
A new high-performance liquid chromatographic chiral stationary phase (CSP)
was prepared from (S)-N-(3,5-dimethylbenzoyl)leucine N-phenyl AT-allyl ami
de. The new CSP was applied for the resolution of N-(3,5-dinitrobenzoyl)-al
pha -amino amides and esters and the chromatographic resolution results wer
e compared with those on another CSP derived from (S)-N-(3,5-dimethoxylbenz
oyl)leucine N-phenyl N-allyl amide. The new CSP was found to exert greater
enantioselectivity than the other one. These results are contrary to what w
as expected from the reciprocity of chiral recognition. From these results
it was concluded that the reciprocity of chiral recognition should be used
with some degree of care in developing effective CSPs or in predicting chro
matographic resolution behaviors. (C) 2001 Elsevier Science BN. All rights
reserved.