U. Achleitner et al., The beneficial effect of basic life support on ventricular fibrillation mean frequency and coronary perfusion pressure, RESUSCITAT, 51(2), 2001, pp. 151-158
Background and objective: Chest compressions before initial defibrillation
attempts have been shown to increase successful defibrillation. This animal
study was designed to assess whether ventricular fibrillation mean frequen
cy after 90 s of basic life support cardiopulmonary resuscitation (CPR) may
be used as an indicator of coronary perfusion and mean arterial pressure d
uring CPR. Methods and results: After 4 min of ventricular fibrillation car
diac arrest in a porcine model. CPR was performed manually for 3 min. Mean
ventricular fibrillation frequency and amplitude, together with coronary pe
rfusion and mean arterial pressure were measured before initiation of chest
compressions, and after 90 s and 3 min of basic life support CPR. Increase
s in fibrillation mean frequency correlated with increases in coronary perf
usion and mean arterial pressure after both 90 s (R = 0.77, P < 0.0001, n =
30; R = 0.75, P < 0.0001, n = 30, respectively) and 3 min (R = 0.61, P < 0
.001, n = 30; R = 0.78, P < 0.0001, n = 30, respectively) of basic life sup
port CPR. Increases in fibrillation mean amplitude correlated with increase
s in mean arterial pressure after both 90 s (R = 0.46, P < 0.01; n = 30) an
d 3 min (R = 0.42, P < 0.05, n = 30) of CPR. Correlation between fibrillati
on mean amplitude and coronary perfusion pressure was not significant both
at 90 s and 3 min of CPR. Conclusions: In this porcine laboratory model, 90
s and 3 thin of CPR improved ventricular fibrillation mean frequency, whic
h correlated positively with coronary perfusion pressure, and mean arterial
pressure. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.