Association of T102C polymorphism of the 5-HT2A receptor gene with pyschiatric status in fibromyalgia syndrome

Serotonin (5-HT) is a key neurotransmitter in the central nervous system. I t is suggested that serotonergic dysfunction may be involved in the pathoph ysiology of fibromyalgia syndrome (FS). In this study, we aimed to investig ate T102C polymorphism of the 5-HT2A receptor gene in FS. Fifty-eight patie nts with FS and 58 unrelated healthy volunteer controls were included in th e study. In both groups, the C/C, C/T, and T/T genotypes of the 5-HT gene w ere represented in 31% (22.4% in controls), 50% (53.4%), and 19% (24.1%), r espectively. The 5-HT2A receptor gene polymorphism results were not signifi cantly different between patients and controls (chi squared test, P > 0.05) . There was a significant correlation between patients with the T/T genotyp e and the subgroup according to the SCL-90-R test, (analysis of variance, P < 0.05). We also saw that patients with the T/T genotype had the lowest pa in threshold. Conclusion. T102C polymorphism of the 5-HT2A receptor gene is not associated with the etiology of FS. Our results also indicate that the T/T genotype may be responsible for psychiatric symptoms of FS.