Antiplatelet therapy for a pregnant woman with a mechanical aortic valve: Report of a case

A 24-year-old woman, who had undergone an aortic valve replacement with a 2 1-mm St. Jude Medical mechanical aortic valve, wished to have a child. She visited our department because she was aware of the risks associated with p regnancy while undergoing anticoagulant therapy using warfarin potassium. T he patient opted to undergo the recommended alternative method involving th e use of antiplatelet agents (dipyridamole, ticlopidine, and aspirin) in pl ace of warfarin potassium. Antiplatelet agents were administered while regu larly monitoring the platelet aggregability along with the coagulation and fibrinolytic activity. At the 36th week of gestation, antiplatelet agents w ere discontinued and instead were followed by continuous heparin infusion. A healthy baby was delivered by cesarean section without any complications at the 38th week. Antithrombotic therapy using antiplatelet agents appears to be an effective option for preventing serious problems for pregnant wome n with a mechanical heart valve.