The authors carried out an anatomical histological study of the lateral inf
ramalleolar region in order to improve knowledge of a fat pad of the latera
l aspect of the ankle which is not mentioned in most anatomical texts. Twen
ty-four ankles, from 12 cadavers, free of any local pathology or malformati
on, were studied. Twenty ankles were dissected, of which, five had samples
taken for histological examination. Colored latex was injected into the joi
nt cavities of the last four ankles before anatomical cuts were made in thr
ee planes. This study allowed the description of the fat pad which we have
called the lateral inframalleolar fat pad (LIMFP). It is oval and made up o
f a classical unilocular fatty tissue which is clearly distinct from the su
bcutaneous plane. We have defined its relationships and in particular, the
neurovascular ones. The sural nerve which supplies cutaneous sensation to p
art of the 5(th) toe runs over the surface of the fat pad. It is accompanie
d on this part of its course by the short saphenous vein which gives off a
medial perforator which traverses the LIMFP. Because of these neurovascular
relationships, the LIMFP may play a role in the pathophysiology of neuralg
ias of the lateral aspect of the 5(th) toe or of the 4(th) digital interspa
ce. It should be recognized before any operations on the lower limbs, in pa
rticular, before any plastic surgical liposuction, in order to optimize the
resection volume to prevent inaesthetic over correction or under correctio
ns which are often confused with residual edema.