One-pot three-step solution phase syntheses of thiohydantoins using microwave heating

Authors
Ohberg, L Westman, J
Citation
L. Ohberg et J. Westman, One-pot three-step solution phase syntheses of thiohydantoins using microwave heating, SYNLETT, (12), 2001, pp. 1893-1896
Citations number
21
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
12
Year of publication
2001
Pages
1893 - 1896
Database
ISI
SICI code
0936-5214(200112):12<1893:OTSPSO>2.0.ZU;2-O
Abstract
An efficient one-pot three-step solution phase protocol suitable for librar y syntheses of thiohydantoins was developed. The reactions included are in the following order, Negishi or Suzuki CC coupling reactions, reductive ami nation and finally a cyclisation reaction. Protocols using a solid supporte d reagent and protocols suitable for combinatorial chemistry were developed . all including microwave heating.