A method for selective N-Boc deprotection on Wang resin

Authors
Trivedi, HS Anson, M Steel, PG Worley, J
Citation
Hs. Trivedi et al., A method for selective N-Boc deprotection on Wang resin, SYNLETT, (12), 2001, pp. 1932-1934
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
12
Year of publication
2001
Pages
1932 - 1934
Database
ISI
SICI code
0936-5214(200112):12<1932:AMFSND>2.0.ZU;2-8
Abstract
A simple, inexpensive and efficient method for the selective cleavage of N- Boc protecting group under acidic conditions on high load Wang resin is des cribed. This method employs the use Of concd Sulfuric acid in 1.4-dioxan an d provides an efficient process for the complete Boc deprotection with mini mal loss of substrate through cleavage from resin.