Solid-phase synthesis of bis-cyclic guanidines from tripeptides

Authors
Acharya, AN Ostresh, JM Houghten, RA
Citation
An. Acharya et al., Solid-phase synthesis of bis-cyclic guanidines from tripeptides, TETRAHEDRON, 57(50), 2001, pp. 9911-9914
Citations number
28
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
50
Year of publication
2001
Pages
9911 - 9914
Database
ISI
SICI code
0040-4020(200112)57:50<9911:SSOBGF>2.0.ZU;2-S
Abstract
An efficient method for the solid-phase synthesis of bis-cyclic guanidines from reduced tripeptides is described. The exhaustive reduction of the trip eptides generated tetra-amines that on treatment with cyanogen bromide, aff orded bis-cyclic guanidines having three separate variable positions. (C) 2 001 Elsevier Science Ltd. All rights reserved.