Molecular motors: from one motor many tails to one motor many tales

Kinesin and dynein molecular motor proteins generate the movement of a wide variety of materials in cells. Such movements are crucial for many differe nt cellular and developmental functions, including organelle movement, loca lization of developmental determinants, mitosis, meiosis and possibly long- range signaling in neurons. Kinesins that control the dynamics of microtubu les have also been discovered, Recent work has begun to identify processes in which defective molecular motor function can cause human disease.