Death-receptor contribution to the germinal-center reaction

Both helper T cells and follicular dendritic cells play crucial roles in th e germinal-center (GC) reaction. One of their key functions is to provide G C B cells with anti-apoptotic signals during their growth, diversification of antibody repertoire and positive selection. Dysregulation of the mechani sms that control B-cell apoptosis in the GC could cause hyperplasia, endang er self-tolerance or impair dramatically the efficiency of the humoral resp onse. This article discusses how the death receptor Fas and components of i ts signaling machinery contribute to the GC reaction.