Malaria vaccine trials in a wormy world

Authors
Citation
M. Nacher, Malaria vaccine trials in a wormy world, TRENDS PARA, 17(12), 2001, pp. 563-565
Citations number
37
Categorie Soggetti
Microbiology
Journal title
TRENDS IN PARASITOLOGY
ISSN journal
14714922 → ACNP
Volume
17
Issue
12
Year of publication
2001
Pages
563 - 565
Database
ISI
SICI code
1471-4922(200112)17:12<563:MVTIAW>2.0.ZU;2-Z
Abstract
The promising malaria vaccine candidates that have been tested in the field have, so far, yielded disappointing and, at times, conflicting results. Co nsiderable efforts are being made to isolate new immunogenic molecules. How ever, the fact that most populations in malaria endemic areas are also infe cted by helminths appears to be overlooked. Helminth-related hyporesponsive ness to tetanus or cholera vaccines, and the interactions between malaria p arasites and helminths, raise the possibility that a potent malaria vaccine will not be identified in helminth-infected populations, thus necessitatin g a change in vaccine trial design.