Doppler quantitative measures by region to discriminate prostate cancer

This study was conducted to assess if sonographic discrimination between he althy and cancerous prostate tissue might be improved using regional analys is of ultrasound (US) Doppler measures. A total of 39 subjects underwent 3- D Doppler sonography before radical prostatectomy. Cancer locations were id entified from hematoxylin and eosin (H&E)-stained slides. Three prostate da ta volumes consisting of a frequency shift and power-mode Doppler US and wh ole mount histology images were spatially registered for each prostate, the n divided into entirely 1 mL-sized regions of cancerous or noncancerous tis sue. Each prostate was visually divided into a peripheral and a periurethra l region within which US Doppler measures were calculated. Receiver operati ng characteristic (ROC) and simulated biopsy analyses within each prostate were performed. Mean speed in colored pixels (V) and speed-weighted pixel d ensity (SWD) are good discriminators for prostate cancer in the periurethra l and the peripheral regions, respectively. Using SWD in a simulated biopsy yields increased cancer detection in the peripheral region. (C) 2001 World Federation for Ultrasound in Medicine & Biology.