An overview on methanol conversion in high-rate anaerobic reactors is prese
nted, with the focus on technological as well as microbiological aspects. T
he simple C1-compound methanol can be degraded anaerobically in a complex w
ay, in which methanogens, sulfate reducing bacteria and homoacetogens inter
act cooperatively or competitively at substrate level. This interaction has
large technological implications as it determines the final product of met
hanol mineralization, methane or carbon dioxide. The degradation route of m
ethanol may be entirely different when environmental conditions change. Dir
ect methanogenesis from methanol seems the predominant mineralization route
under mesophilic conditions both in the absence and the presence of sulfat
e. Under thermophilic conditions methanol oxidation to carbon dioxide and h
ydrogen appears to play an important role. The UASB technology for mesophil
ic digestion of methanolic waste has presently reached full-scale maturity.
The potential of methanol as feedstock for anaerobic processes is discusse
d.