NO synthase and cardiovascular gene therapy

Molecular biology research of vascular remodeling paved the way to novel th erapeutic approaches in experimental cardiology. Using gene transfer method s in various animal models, it has been shown that overexpression of nitric oxide synthase (NOS) can inhibit neointimal lesion proliferation. This rev iew summarizes pivotal data regarding NO synthase gene manipulation in the cardiovascular system which enabled transition of this experimental approac h from the bench to the clinical arena.