E. Forestier et al., PROGNOSTIC IMPACT OF BONE-MARROW KARYOTYPE IN CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA - SWEDISH EXPERIENCES 1986-91, Acta paediatrica, 86(8), 1997, pp. 819-825
The prognostic value of cytogenetic classification in acute lymphoblas
tic leukaemia (ALL) was evaluated in Swedish children below 16 years o
f age (n = 372) diagnosed between 1986 and 1991. A bone marrow karyoty
pe was obtained in 281 cases, of which 149 (53%) showed clonal abnorma
lities, Event-free survival (p-EFS) was 0.64-0.69 in patients with dip
loid and pseudodiploid karyotype. Patients with massive hyperdiploidy
(> 50 chromosomes) had the best outcome (p-EFS = 0.76) and those with
hypodiploidy (< 46 chromosomes) had the worst (p-EFS = 0.33). White bl
ood cell count and age were the strongest predictors of outcome. The k
aryotype reached borderline significance. The diagnostic karyotype was
also a predictor of outcome after relapse, with hyperdiploid patients
doing better than the others. The presence of a structural chromosoma
l abnormality did not constitute a negative prognostic factor when int
ensive chemotherapy was given.