NATURAL OCCURRENCE OF 2'-PHOSPHO-CYCLIC ADP RIBOSE IN MAMMALIAN-TISSUES

Authors
VU CQ COYLE DL JACOBSON MK
Citation
Cq. Vu et al., NATURAL OCCURRENCE OF 2'-PHOSPHO-CYCLIC ADP RIBOSE IN MAMMALIAN-TISSUES, Biochemical and biophysical research communications, 236(3), 1997, pp. 723-726
Citations number
14
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
236
Issue
3
Year of publication
1997
Pages
723 - 726
Database
ISI
SICI code
0006-291X(1997)236:3<723:NOO2AR>2.0.ZU;2-4
Abstract
2'-Phospho-cyclic ADP-ribose (P-cADPR) is a newly identified Ca2+-mobi lizing agent derived from NADP that stimulates intracellular Ca2+ rele ase by a mechanism distinct from inositol 1,4,5-trisphosphate. In this report, we show that P-cADPR is an endogenous metabolite in bovine ti ssues with basal levels ranging from 17.6 to 89.5 fmol/mg protein. The natural occurrence of this Ca2+-mobilizing nucleotide provides a pote ntial link between NADP(H) metabolism and regulation of Ca2+ homeostas is. (C) 1997 Academic Press.