REVERSIBLE SENSORINEURAL HEARING-LOSS AFTER RENAL-TRANSPLANT IMMUNOSUPPRESSION WITH OKT3 (MUROMONAB-CD3)

Authors
HARTNICK CJ COHEN AF SMITH RV
Citation
Cj. Hartnick et al., REVERSIBLE SENSORINEURAL HEARING-LOSS AFTER RENAL-TRANSPLANT IMMUNOSUPPRESSION WITH OKT3 (MUROMONAB-CD3), The Annals of otology, rhinology & laryngology, 106(8), 1997, pp. 640-642
Citations number
8
Categorie Soggetti
Otorhinolaryngology
Journal title
The Annals of otology, rhinology & laryngology → ACNP
ISSN journal
00034894
Volume
106
Issue
8
Year of publication
1997
Pages
640 - 642
Database
ISI
SICI code
0003-4894(1997)106:8<640:RSHARI>2.0.ZU;2-U
Abstract
Reversible and irreversible ototoxicity has been documented following the administration of various therapeutic agents. Reversible hearing l oss is a known complication following the administration of quinine, s alicylates and other nonsteroidal anti-inflammatory drugs, and erythro mycin. We report a case of reversible hearing loss following OKT3 (mur ine monoclonal antibody CD3) administration. OKT3, a monoclonal antibo dy used as an immunosuppressant following cadaveric renal transplants, was associated with a transient sensorineural hearing loss that rever sed following discontinuation of OKT3.