1,3,4-THIADIAZOLE DERIVATIVES .7. PLATINUM(II) COMPLEXES OF SOME 1,3,4-THIADIAZOLE DERIVATIVES POSSESSING CARBONIC-ANHYDRASE INHIBITORY PROPERTIES

Authors
OLAR R MARINESCU D POPESCU C SUPURAN CT
Citation
R. Olar et al., 1,3,4-THIADIAZOLE DERIVATIVES .7. PLATINUM(II) COMPLEXES OF SOME 1,3,4-THIADIAZOLE DERIVATIVES POSSESSING CARBONIC-ANHYDRASE INHIBITORY PROPERTIES, Revue Roumaine de Chimie, 42(2), 1997, pp. 111-114
Citations number
30
Categorie Soggetti
Chemistry
Journal title
Revue Roumaine de Chimie → ACNP
ISSN journal
00353930
Volume
42
Issue
2
Year of publication
1997
Pages
111 - 114
Database
ISI
SICI code
0035-3930(1997)42:2<111:1D.PCO>2.0.ZU;2-2
Abstract
Platinum(II) coordination compounds containing 2-amino-5-mercapto-1,3, 4-thiadiazole 4 (AMT), 2-acetamido-5-mercapto-1,3,4-thiadiazole 5 (AcM T) and 5-ureido-1,3,4-thiadiazolyl-2-sulfonamide 6 (UTS) as ligands we re prepared and characterised by elemental analysis, spectroscopic, co nductometric and magnetic measurements. The complexes were tested as i nhibitors of carbonic anhydrase, and one of them (containing the sulfo namide) behaves as strong inhibitor.