ELEVATION OF SERUM IGF-1 RATHER THAN SEX STEROIDS PRECEDES PROLIFERATIVE DIABETIC-RETINOPATHY IN MAURIACS SYNDROME

Authors
CHANTELAU E SEPPEL T ALTHAUS C SCHONAU E
Citation
E. Chantelau et al., ELEVATION OF SERUM IGF-1 RATHER THAN SEX STEROIDS PRECEDES PROLIFERATIVE DIABETIC-RETINOPATHY IN MAURIACS SYNDROME, Hormone research, 48(3), 1997, pp. 131-134
Citations number
23
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Hormone research → ACNP
ISSN journal
03010163
Volume
48
Issue
3
Year of publication
1997
Pages
131 - 134
Database
ISI
SICI code
0301-0163(1997)48:3<131:EOSIRT>2.0.ZU;2-R
Abstract
We report the case of a 21-year-old man with Mauriac's syndrome, in wh om diabetic retinopathy progressed to the proliferative state despite slightly improved glycemic control and completely suppressed sex stero ids (by a GnRH agonist). However, a gradual increase in serum IGF-1 fr om 162 to 482 ng/ml over 9 months clearly preceded retinal deteriorati on, which responded to panretinal laser coagulation. We conclude that substantial elevation of serum IGF-1 may be another risk factor for th e progression of mild diabetic retinopathy to the proliferative state.