APPLICATION OF ORGANOLITHIUM AND RELATED REAGENTS IN SYNTHESIS .15. ACONCISE REGIOSPECIFIC CONVERSION OF PICOLINIC ACIDS AND ISONICOTINIC ACIDS INTO 2-BENZOYLNICOTINIC AND 4-BENZOYLNICOTINIC ACIDS
J. Epsztajn et al., APPLICATION OF ORGANOLITHIUM AND RELATED REAGENTS IN SYNTHESIS .15. ACONCISE REGIOSPECIFIC CONVERSION OF PICOLINIC ACIDS AND ISONICOTINIC ACIDS INTO 2-BENZOYLNICOTINIC AND 4-BENZOYLNICOTINIC ACIDS, Synthetic communications, 24(13), 1994, pp. 1789-1798
The synthesis of the azaphthalides (7) and (8) and their conversion in
to the corresponding 2- and 4-benzoyl-3-hydroxymethylpyridines (9) and
(10), very useful precursors of the 2- and 4-benzoylated nicotinic ac
ids (11) and (12), as a way of regiospecific transformation of the pic
olin- and isonicotinanilides (1) and (2) into nicotinic acid derivativ
es, is described.