EXERCISE TRAINING BY INDIVIDUALS WITH PREDIALYSIS RENAL-FAILURE - CARDIORESPIRATORY ENDURANCE, HYPERTENSION, AND RENAL-FUNCTION

The purpose of this study was to determine the effects of 4 months of exercise training (ET) on cardiorespiratory function and endurance, bl ood pressure, muscle strength, hematology, blood lipids, and renal fun ction in individuals with chronic renal failure (CRF) who were not yet on dialysis. Sixteen subjects were recruited to volunteer for partici pation in this study, but only eight completed all study phases. Subje cts were first evaluated before and after a 2-month baseline (BL1 and BL2), after 4 months of ET, and again after 2 months of detraining (DT ). ET did not change hematology, blood lipids, or echocardiographic me asurements of left ventricular function and mass. Resting systolic and diastolic blood pressures decreased significantly from BL after the E T (146 +/- 15.7/87 +/- 9 mm Hg to 124 +/- 17.5/78 +/- 9.5 mm Hg; P < 0 .02), and then increased significantly after DT (139 +/- 14.7 mm Hg an d 87 +/- 9.9 mm Hg; P < 0.01). Peak oxygen consumption (pVO(2)) change d significantly during the study (1.3 +/- 0.3 L/min, 1.5 +/- 0.3 L/min , and 1.4 +/- 0.3 L/min for BL2, ET, and DT, respectively; P < 0.02), as did the VO2 at the ventilatory threshold (0.65 +/- 0.18 L/min, 0.92 +/- 0.19 L/min, and 0.68 +/- 0.23 L/min for BL2 ET, and DT, respectiv ely; P < 0.01). Knee flexion peak torque increased after ET (43.4 +/- 25.6 Nm to 51.0 +/- 30.5 Nm; P < 0.02). GFR, as measured by creatinine clearance, continued to deteriorate during the course of the study (2 5.3 +/- 12.0 mL/min, 21.8 +/- 13.2 mL/min, and 21.8 +/- 13.2 mL/min fo r BL2, ET, and DT, respectively; P < 0.001). Individuals with predialy sis ORF who undergo ET improve in functional aerobic capacity, muscula r strength, and blood pressure. (C) 1997 by the National Kidney Founda tion, Inc.