Yj. Yoon et Cy. Choi, NUTRIENT EFFECTS ON FK-506, A NEW IMMUNOSUPPRESSANT, PRODUCTION BY STREPTOMYCES SP IN A DEFINED MEDIUM, Journal of fermentation and bioengineering, 83(6), 1997, pp. 599-603
A basal defined medium was developed for production of FH-506, a novel
immunosuppressant, by Streptomyces sp. MA6858 (ATCC 55098) involving
lactate, leucine, glucose, phosphate, etc, and the actions of differen
t medium constituents on growth and production were examined.