HIGHLY REGIO-SELECTIVE AND STEREOSELECTIVE ALKYLSUBSTITUTION WITH COPPER REAGENTS FOR THE CONSTRUCTION OF CHIRAL TRIFLUOROMETHYLATED QUATERNARY CARBON CENTERS

Authors
HIRAOKA S YAMAZAKI T KITAZUME T
Citation
S. Hiraoka et al., HIGHLY REGIO-SELECTIVE AND STEREOSELECTIVE ALKYLSUBSTITUTION WITH COPPER REAGENTS FOR THE CONSTRUCTION OF CHIRAL TRIFLUOROMETHYLATED QUATERNARY CARBON CENTERS, Chemical communications, (16), 1997, pp. 1497-1498
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
16
Year of publication
1997
Pages
1497 - 1498
Database
ISI
SICI code
1359-7345(1997):16<1497:HRASAW>2.0.ZU;2-8
Abstract
A new route for the asymmetric construction of quaternary carbon centr es containing a trifluoromethyl group has been established using a hig hly regio-and stereo-selective S(N)2' reaction of organocopper and org anocuprate reagents with allylic mesylates 4 and 8.