SEQUENTIAL MICHAEL ADDITION CARBOCYCLIZATION REACTIONS - A PALLADIUM-MEDIATED APPROACH TO HIGHLY FUNCTIONALIZED 3-METHYLENETETRAHYDROFURANS

Authors
MARAT X MONTEIRO N BALME G
Citation
X. Marat et al., SEQUENTIAL MICHAEL ADDITION CARBOCYCLIZATION REACTIONS - A PALLADIUM-MEDIATED APPROACH TO HIGHLY FUNCTIONALIZED 3-METHYLENETETRAHYDROFURANS, Synlett, (7), 1997, pp. 845
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
7
Year of publication
1997
Database
ISI
SICI code
0936-5214(1997):7<845:SMACR->2.0.ZU;2-Z
Abstract
A one-pot procedure for the preparation of highly functionalized 3-met hylenetetrahydrofurans is described. The methodology is based on an ox ygen nucleophile initiated Michael addition of propargyl alcohols to a lkylidene or arylidenemalonates followed in situ by a palladium-mediat ed exo-dig cyclization.