THE SYNTHESIS OF N,N'-O-TRISUBSTITUTED HYDROXYLAMINES VIA A MILD REDUCTIVE ALKYLATION PROCEDURE - AN IMPROVED SYNTHESIS OF THE MMI BACKBONE

Authors
SWAYZE EE SANGHVI YS
Citation
Ee. Swayze et Ys. Sanghvi, THE SYNTHESIS OF N,N'-O-TRISUBSTITUTED HYDROXYLAMINES VIA A MILD REDUCTIVE ALKYLATION PROCEDURE - AN IMPROVED SYNTHESIS OF THE MMI BACKBONE, Synlett, (7), 1997, pp. 859
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
7
Year of publication
1997
Database
ISI
SICI code
0936-5214(1997):7<859:TSONHV>2.0.ZU;2-O
Abstract
A mild procedure for the synthesis of N,N',O-trisubstituted hydroxylam ines via the reductive alkylation of N,O-disubstituted hydroxylamines with both aldehydes and ketones has been developed. We have applied th is reaction to the synthesis of methylene(methylimino) (MMI) linked di meric nucleosides, which are of potential use in antisense application s.