ANE-1,4,7-TRYLTRIMETHYLENETRIS-(PHENYLPHOSPHINATE) ENFORCES OCTAHEDRAL GEOMETRY - CRYSTAL AND SOLUTION STRUCTURES OF ITS METAL-COMPLEXES AND COMPARATIVE BIODISTRIBUTION STUDIES OF RADIOLABELED INDIUM AND GALLIUM COMPLEXES

ane-1,4,7-triyltrimethylenetris(phenylphosphinate) formed C3-symmetric complexes with the divalent ions of Co, Ni, Cu and Zn and structurall y similar complexes with the trivalent ions of Fe, Co, Ga and In. For each of the eight crystal structures examined, the ligand adopts the s ame rigid conformation and a single chiral diastereoisomer is formed ( RRR or SSS at each stereogenic phosphorus centre). The geometry around the metal centre is slightly distorted octahedral. The copper(II) com plex only undergoes a Jahn-Teller distortion below 100 K, and the pink cobalt(II) complex only slowly oxidises to the dark blue cobalt(III) complex. The chiral gallium(III) complex may be resolved by preparativ e HPLC, and its H-1 NMR spectrum has been fully assigned with the aid of two-dimensional methods. The indium-111 and gallium-67 complexes ha ve been examined in vivo and exhibit selective biliary clearance assoc iated with their lipophilic nature.