THE HUMAN-CHROMOSOME-3 GENE-CLUSTER ACY1-CACNA1D-ZNF64-ATP2B2 IS EVOLUTIONARILY CONSERVED IN ATELES-PANISCUS CHAMEK (PLATYRRHINI, PRIMATES)

Comparative mapping of Ateles paniscus chamek and man indicated that f our human 3p markers are syntenic in this karyotypically rearranged ne otropical primate. The evolutionary conservation of this gene cluster includes three adjacent human shortest regions of overlap (SROs): 3p21 .1 (ACY1), 3p21.3-->p21.2 (CACNA1D), and 3p21.3 (ZNF64). A fourth synt enic marker (ATP2B2), at a more distal human SRO (3p26-->p25), indicat ed that human 3pter-->p14 is evolutionarily conserved in Ateles chromo some 3 (APC 3). Conversely, allocations of two human 3q markers (AGTR1 and IL12A) clearly excluded APC 3. Finally, allocation of the major h istocompatibility complex class I genes further confirmed human 6p-6q dissociations Ateles.