Hn. Seuanez et al., THE HUMAN-CHROMOSOME-3 GENE-CLUSTER ACY1-CACNA1D-ZNF64-ATP2B2 IS EVOLUTIONARILY CONSERVED IN ATELES-PANISCUS CHAMEK (PLATYRRHINI, PRIMATES), Cytogenetics and cell genetics, 77(3-4), 1997, pp. 314-317
Comparative mapping of Ateles paniscus chamek and man indicated that f
our human 3p markers are syntenic in this karyotypically rearranged ne
otropical primate. The evolutionary conservation of this gene cluster
includes three adjacent human shortest regions of overlap (SROs): 3p21
.1 (ACY1), 3p21.3-->p21.2 (CACNA1D), and 3p21.3 (ZNF64). A fourth synt
enic marker (ATP2B2), at a more distal human SRO (3p26-->p25), indicat
ed that human 3pter-->p14 is evolutionarily conserved in Ateles chromo
some 3 (APC 3). Conversely, allocations of two human 3q markers (AGTR1
and IL12A) clearly excluded APC 3. Finally, allocation of the major h
istocompatibility complex class I genes further confirmed human 6p-6q
dissociations Ateles.