COMPARATIVE ANTIBACTERIAL ACTIVITY OF CEF PODOXIME AGAINST HAEMOPHILUS-INFLUENZAE, STREPTOCOCCUS-PYOGENES, STREPTOCOCCUS-PNEUMONIAE, AND MORAXELLA-CATARRHALIS

The antimicrobial activity of cefpodoxime (Podomexef(R), CAS 80210-62- 4) against 236 clinical isolates of H. influenzae, Moraxella catarrhal is, Streptococcus pyogenes and Streptococcus pneumoniae was investigat ed and compared with that of another 8 commonly used oral antibiotics. beta-Lactamase negative, beta-lactamase positive and multiresistant s trains of H. influenzae were inhibited by cefpodoxime at a concentrati on of 0.13 mg/l. 10% of Moraxella catarrhalis isolates were moderately susceptible to cefpodoxime, with minimum inhibitory concentration (MI C) of cefpodoxime ranging between 0.13 and 2.0 mg/l. All isolates of S treptococcus pyogenes and Streptococcus pneumoniae were susceptible to less than or equal to 0.25 mg/l cefpodoxime. Cefpodoxime was clearly more active than the older oral cephalosporins against all species tes ted. The activity was comparable to that of cefixime against all speci es except Streptococcus pneumoniae, against which cefpodoxime was more active than cefixime.