Wl. Hennrikus et al., SELF-ADMINISTERED NITROUS-OXIDE ANALGESIA FOR PEDIATRIC FRACTURE REDUCTIONS, Journal of pediatric orthopedics, 14(4), 1994, pp. 538-542
We prospectively studied the efficacy and safety of self-administered
nitrous oxide analgesia for 54 children undergoing closed reductions o
f fractures in the emergency department. No child was excluded from en
try into the study because of fracture type. Nitrous oxide was the sol
e source of analgesia. The average Children's Hospital of Eastern Onta
rio pain score (CHEOPS) rated by the emergency medicine physician obse
rving the reduction was 9.1 (range 6-13). Ninety-one percent of childr
en obtained an analgesic effect; however, 46% of children had a CHEOPS
score of greater-than-or-equal-to 10, indicating significant pain. A
statistically significantly higher proportion of failures using nitrou
s-oxide analgesia occurred in patients with completely displaced radiu
s/ulna fractures (p = 0.027). No complications such as vomiting, respi
ratory depression, or a change in oxygen saturation resulted from the
use of nitrous oxide.