SYNTHESIS AND BIOLOGICAL-ACTIVITY OF THE DIPHOSPHORYLPHOSPHONATE DERIVATIVES OF (-CIS-9-(4'-HYDROXYCYCLOPENT-2'-ENYL)GUANINE AND (-)-CIS-9-(4'- HYDROXYCYCLOPENT-2'-ENYL)GUANINE())

Authors
MERLO V ROBERTS SM STORER R BETHELL RC
Citation
V. Merlo et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF THE DIPHOSPHORYLPHOSPHONATE DERIVATIVES OF (-CIS-9-(4'-HYDROXYCYCLOPENT-2'-ENYL)GUANINE AND (-)-CIS-9-(4'- HYDROXYCYCLOPENT-2'-ENYL)GUANINE()), Journal of the Chemical Society. Perkin transactions. I, (11), 1994, pp. 1477-1481
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
11
Year of publication
1994
Pages
1477 - 1481
Database
ISI
SICI code
0300-922X(1994):11<1477:SABOTD>2.0.ZU;2-M
Abstract
The carbovir triphosphate analogue 10 and its enantiomer 11 have been synthesized and tested as inhibitors of HIV-reverse transcriptase; the enantiomer 11, more remotely resembling natural nucleotides in stereo chemical terms, is surprisingly the more active compound.