Hf. Chen et al., MECHANISMS UNDERLYING STIMULATION OF RAPIDLY ADAPTING RECEPTORS DURING PULMONARY AIR-EMBOLISM IN DOGS, Respiration physiology, 109(1), 1997, pp. 1-13
We investigated the mechanisms underlying stimulation of rapidly adapt
ing receptors (RARs) during pulmonary air embolism (PAE). Impulses wer
e recorded from RARs in 43 anesthetized, open-chest and artificially v
entilated dogs. Forty one out of 56 RARs were stimulated by infusion o
f air into the right atrium (0.2 ml/kg per min for 10 min). As a group
(n = 56), RAR activity increased from a baseline of 1.2 +/- 0.2 to a
peak of 4.3 +/- 0.3 impulses/breath at 8-10 min after the onset of PAE
induction. PAE also caused an increase in total lung resistance and a
decrease in dynamic lung compliance. Studies were repeated in 33 RARs
initially stimulated by PAE. In nine receptors, hyperinflation of the
lungs performed at the termination of the second PAE induction largel
y reversed both the afferent and bronchomotor responses. Furthermore,
the residual PAE-evoked activity subsequent to hyperinflation was almo
st eliminated by elevation in the heart position. In another 24 recept
ors, the responses of RARs to PAE were unaltered by pretreatment with
saline (n = 8) or dimethylthiourea (a hydroxyl radical scavenger; n =
8), but was significantly attenuated by pretreatment with ibuprofen (a
cyclooxygenase inhibitor; n = 8). These results suggest that: (I) the
increased RAR activity following PAE is associated primarily with an
increase in bronchomotor tone and secondarily with the mechanical acti
on of the beating heart impacting on lung tissues; and (2) cyclooxygen
ase products may be involved in this sensory stimulation. (C) 1997 Els
evier Science B.V.