R. Feldmann et al., NECROTIZING CUTANEOUS LESIONS CAUSED BY INTERFERON-BETA INJECTIONS INA PATIENT WITH MULTIPLE-SCLEROSIS, Dermatology, 195(1), 1997, pp. 52-53
We report a patient with multiple sclerosis who was receiving subcutan
eous injections of recombinant interferon beta. During the third month
of treatment, painful necrotizing cutaneous lesions appeared at the i
njection sites. The possible pathogenesis of interferon-induced skin n
ecrosis is discussed.