SEVERE, CHRONIC ANOREXIA AND EXTENSIVE LEG ULCERATIONS AS PRESENTING SIGNS OF PRIMARY SJOGRENS-SYNDROME

We report the case of a 75-year-old woman with a 15-year history of in appetance resulting in weight loss of approximately 40 kg. On physical examination, the skin of the lower extremities was markedly hyperpigm ented with a brown-greyish hue. In addition, the skin of the legs was infiltrated, erythematous, riddled with erosions and necrotic ulcers. Clinical and laboratoy evaluation revealed sicca syndrome, a pronounce d polyclonal hypergammagl obulinemia (60 g/l), high levels of antinucl ear, anti-SSA and anti-SSB antibodies. Histological examination of inv olved skin demonstrated a leukocytoclastic vasculitis.