ECONAZOLE, MICONAZOLE AND SK-AND-F96365 INHIBIT DEPOLARIZATION-INDUCED AND RECEPTOR-OPERATED CONTRACTION OF GUINEA-PIG ISOLATED TRACHEA IN-VITRO

Econazole, miconazole, SK&F 96365 and nifedipine inhibited Ca2+- and d epolarization-induced and receptor-operated contraction of guinea-pig isolated trachea. Econazole, miconazole and SK&F 96365 inhibited hista mine-and methacholine-induced tracheal contraction more than nifedipin e. Nifedipine was more potent in inhibiting KCl-induced contraction. N ifedipine, salbutamol and theophylline, but not econazole, miconazole or SK&F 96365, relaxed KCl, histamine-, and methacholine-precontracted trachea. It appears that in the guinea-pig tracheal smooth muscle, ec onazole, miconazole and SK&F 96365 behave differently from nifedipine, theophylline and salbutamol. Econazole, miconazole and SK&F 96365 are thus introduced as novel antagonists of receptor-operated airway smoo th muscle contraction. (C) 1997 Elsevier Science B.V.