THE RELIABILITY OF THROMBOTIC TENDENCY MEASURED BY INTRAVASCULAR WIRES IN THE RAT

The objective was to determine if the amount of thrombus on two adjace nt wires in an artery or in a vein was similar, and whether an upstrea m wire affected thrombosis on the downstream wire. Two 2cm platinum wi res were placed at adjoining sites in the abdominal vena cava and a fu rther 2 in the abdominal aorta in 26 male and 24 female rats. In the a rtery, mean thrombus weight on the aortic downstream wire, set where t he vessel is narrow, was significantly (p<0.001) less than on the upst ream wire, but the two correlated fairly well correlation coefficient( r=0.608). In the vein, mean thrombus weight deposited in 1 hour was c omparable on the pairs of wires both in males (r=0.819) and females (r =0.805). The mean downstream thrombus was slightly (10%)heavier than t he upstream one both in males and females, a possible effect of vessel diameter, or of an activation by the upstream wire of thrombosis on t he downstream one. An experiment to clarify that issue showed mean dow nstream venous thrombus to be again heavier than mean up-stream in bot h sexes (22 males, 30 females), and heavier than in controls in which no upstream wire was inserted. The platinum wire venous model seems to measure individual thrombotic response in a reasonably reproducible w ay in the rat. Upstream venous wire appears to activate thrombosis dow nstream from it by some 10%. (C) 1997 Elsevier Science Ltd.