EXPRESSION OF CARBONIC-ANHYDRASE IV IN CARBONIC-ANHYDRASE II-DEFICIENT MICE

Authors
BRION LP CAMMER W SATLIN LM SUAREZ C ZAVILOWITZ BJ SCHUSTER VL
Citation
Lp. Brion et al., EXPRESSION OF CARBONIC-ANHYDRASE IV IN CARBONIC-ANHYDRASE II-DEFICIENT MICE, American journal of physiology. Renal, fluid and electrolyte physiology, 42(2), 1997, pp. 234-245
Citations number
41
Categorie Soggetti
Physiology
Journal title
American journal of physiology. Renal, fluid and electrolyte physiology → ACNP
ISSN journal
03636127
Volume
42
Issue
2
Year of publication
1997
Pages
234 - 245
Database
ISI
SICI code
0363-6127(1997)42:2<234:EOCIIC>2.0.ZU;2-A
Abstract
Chronic metabolic acidosis (CMA) in the rabbit upregulates carbonic an hydrase (CA) TV in the proximal convoluted tubule (PCT). This study wa s designed to assess CA IV expression in a model of CMA in the mouse, i.e., congenital deficiency in CA II [CA(II)D]. In female CA(II)D mice , CA IV specific activity but not CA TV immunoreactivity was upregulat ed in the renal cortex, specifically in microdissected PCTs. Western b lot analysis showed higher expression of CA IV immunoreactive protein in renal membranes from males than in those from females.