MODIFICATION OF ACETYLCHOLINESTERASE AS A MECHANISM OF RESISTANCE EO INSECTICIDES

Authors
FOURNIER D MUTERO A
Citation
D. Fournier et A. Mutero, MODIFICATION OF ACETYLCHOLINESTERASE AS A MECHANISM OF RESISTANCE EO INSECTICIDES, Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 108(1), 1994, pp. 19-31
Citations number
113
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology → ACNP
ISSN journal
13678280
Volume
108
Issue
1
Year of publication
1994
Pages
19 - 31
Database
ISI
SICI code
1367-8280(1994)108:1<19:MOAAAM>2.0.ZU;2-S
Abstract
In insects, acetylcholinesterase is essential for life and its inhibit ion by organophosphorus or carbamate insecticides is lethal. Extensive use of these insecticides to control insect pests has led to resistan t enzymes, less inhibited than the wild type enzyme. Some mutations re sponsible for resistance have been identified. The resulting mutated p roteins present new catalytic properties towards substrates and inhibi tors. The presence of an altered enzyme has several consequences on th e genetics of resistance and maintenance of resistant alleles in natur al populations.