SUPEROXIDE-DISMUTASE, CATALASE AND CELL DIMORPHISM IN CANDIDA-ALBICANS CELLS EXPOSED TO METHANOL AND DIFFERENT TEMPERATURES

The combined effects of methanol and different temperatures on Candida albicans were studied. Growth curve, cell morphology, superoxide dism utase (SOD) and catalase activity levels have been determined. Cell gr owth in each medium was comparable to 28 degrees C and 37 degrees C. T he growth rate was not affected by methanol, in the presence of glucos e, while it was much lower in the absence of sugar. Cell dimorphism ap peared after thermic stress and it was also dependent on the medium co mposition. In all media, both SOD and catalase levels were much higher at 37 degrees C. The presence of methanol per se did not affect the e nzymatic levels, while the absence of glucose gave higher SOD levels.