EFFECT OF METALLOTHIONEIN-I ON MITOCHONDRIAL OXYGEN-CONSUMPTION

Authors
SIMPKINS CO ZHAO HL TORRENCE CA
Citation
Co. Simpkins et al., EFFECT OF METALLOTHIONEIN-I ON MITOCHONDRIAL OXYGEN-CONSUMPTION, Life sciences, 55(3), 1994, pp. 221-226
Citations number
16
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
55
Issue
3
Year of publication
1994
Pages
221 - 226
Database
ISI
SICI code
0024-3205(1994)55:3<221:EOMOMO>2.0.ZU;2-D
Abstract
The effect of the stress-induced, cysteine-rich protein, metallothione in I (MT), on oxygen consumption by rat liver mitochondria was studied . Using a Clark-type oxygen electrode we found that electron transport from succinate to oxygen was enhanced by MT whereas ADP-initiated oxy gen consumption was inhibited by MT. The MT effect was concentration d ependent. No evidence was found for the provision by MT of an alternat e pathway to oxygen.