We report on a 3-year-old boy with growth retardation, alopecia, pseud
oanodontia, and optic atrophy. This is the 18th known and the first Eg
yptian case of GAPO syndrome. Electron microscopic examination of ging
ival biopsy showed excessive collagen Fibres and endothelial vacuolisa
tion, suggesting involvement of extracellular pathological collagenosi
s.