The patient was a 30 year-old man. He had no previous history. For sev
eral months he experienced a slowly progressive horizontal diplopia wh
ich was the expression of a bilateral third cranial nerve palsy with a
n intact intrinsic component, Muscular or neuro-muscular pathology as
myasthenia was initially suspected but not confirmed. CT scan and MRI
revealed an atypical left temporo-insular lesion which led us to discu
ss a chronic inflammatory pathology as sarcoidosis or a tumoral proces
s. Finally cerebral biopsy showed a high grade oligodendroglioma. Symp
tomatology was attributed to infiltration of the peduncles from this t
umor. Such a case has never been seen before, Early neuroradiological
explorations would be useful in case of clinical suspicion of cranial
nerve palsy.