ANGIOTROPIC LYMPHOMA WITH ENDOCRINE INVOLVEMENT

Aims: Two cases of angiotropic high-grade B-cell lymphoma are describe d in which involvement of endocrine glands was a prominent feature. Me thods and results: One patient had marked unilateral adrenomegaly due to lymphoma within adrenal blood vessels. He is alive 5 years after pr esentation following combination chemotherapy. The diagnosis was made at autopsy in the second patient who presented with pyrexia of unknown origin and had hypothyroidism and a thyroid nodule. The thyroid gland and pituitary showed striking involvement by angiotropic lymphoma and the thyroid nodule was a cavernous haemangioma heavily colonized by l ymphoma cells. Conclusions: Our cases illustrate endocrine organ manif estations of this rare disease. The condition may respond to combinati on chemotherapy.