FREQUENT INVOLVEMENT OF CHROMOSOME-1, CHROMOSOME-3, CHROMOSOME-7 AND CHROMOSOME-8 IN SPLENIC MARGINAL ZONE B-CELL LYMPHOMA

Authors
SOLE F WOESSNER S FLORENSA L ESPINET B MOLLEJO M MARTIN P PIRIS MA
Citation
F. Sole et al., FREQUENT INVOLVEMENT OF CHROMOSOME-1, CHROMOSOME-3, CHROMOSOME-7 AND CHROMOSOME-8 IN SPLENIC MARGINAL ZONE B-CELL LYMPHOMA, British Journal of Haematology, 98(2), 1997, pp. 446-449
Citations number
12
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
98
Issue
2
Year of publication
1997
Pages
446 - 449
Database
ISI
SICI code
0007-1048(1997)98:2<446:FIOCCC>2.0.ZU;2-N
Abstract
We have studied 19 cases of splenic marginal zone B-cell lymphoma (SMZ BCL) combining cytological features, conventional cytogenetics, and in situ hybridization (ISH) techniques. A clonal chromosome abnormality was found in 11/19 patients (58%), The more frequent recurrent abnorma lities were: del(3), del (7q), and involvement of chromosomes 1, 3, 7 and 8. No patient showed the translocation t(11;14)(q13;q32), An outst anding finding was the low incidence of trisomy 3 (36%) compared to pa tients with MALT lymphoma, These findings support the interpretation t hat SMZBCL is a distinct lymphoproliferative disorder.