HIGH SERUM LEVELS OF CA125 AND INTERLEUKIN-6 IN A PATIENT WITH KI-1 LYMPHOMA

Mie report a 53-year-old-man with an aggressive Ki-l lymphoma who had high serum CA125, a marker protein of the epithelial ovarian cancer, a nd interleukin-6 (IL-6) concentrations. Both CA125 and IL-6 levels dec reased after chemotherapy and elevated with disease progression. The p atient's lymphoma cells obtained before chemotherapy grew continuously in vitro, were IL-6 dependent and were found to secrete CA125 in cult ure medium. These results indicate that CA125 can be secreted by Ki-l lymphoma cells and IL-6 may promote the growth of Ki-1 lymphoma cells.