EPSTEIN-BARR-VIRUS ASSOCIATED B-CELL LYMPHOMA AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA

Epstein-Barr virus associated lymphoproliferative disease after autolo gous bone marrow transplantation (ABMT) has rarely been reported. We r eport a case of B-cell lymphoma following ABMT for T-acute lymphoblast ic leukaemia: bone marrow was purged in vitro with monoclonal antibodi es to remove T cells. Immunoglobulin and T-cell receptor gene rearrang ement studies were used to demonstrate clonality and to show that this patient developed a second neoplasm after ABMT. EBV proteins and geno me (type A) were present in post-transplantation lymphoma, suggesting a causative role in its development.