NEW GENETIC-LOCI IN NEUROBLASTOMA

Neuroblastoma has been associated genetically with amplification of th e MYCN gene and with alteration of the short arm of chromosome 1 (1p). In pursuit of determining the spectrum of genetic loci damaged recurr ently in neuroblastoma cells we have recently encountered two addition al types of genomic abnormalities: i.) duplication of the MYCN gene on chromosome 2p24; and ii) amplification of the gene MDM2. These altera tions extend the spectrum of genetic lesions in neuroblastoma cells, a lthough their incidence in primary tumor tissues has not been determin ed as yet.