EFFECT OF DIFFERENT COMBINATIONS OF SPARFLOXACIN, OXACILLIN, AND FOSFOMYCIN AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCI

Authors
FERRARA A DOSSANTOS C CIMBRO M GRASSI GG
Citation
A. Ferrara et al., EFFECT OF DIFFERENT COMBINATIONS OF SPARFLOXACIN, OXACILLIN, AND FOSFOMYCIN AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCI, European journal of clinical microbiology & infectious diseases, 16(7), 1997, pp. 535-537
Citations number
15
Categorie Soggetti
Microbiology,"Infectious Diseases
Journal title
European journal of clinical microbiology & infectious diseases → ACNP
ISSN journal
09349723
Volume
16
Issue
7
Year of publication
1997
Pages
535 - 537
Database
ISI
SICI code
0934-9723(1997)16:7<535:EODCOS>2.0.ZU;2-E
Abstract
The in vitro activity of combinations of sparfloxacin/oxacillin, sparf loxacin/fosfomycin, and oxacillin/fosfomycin was investigated against 16 methicillin-resistant Staphylococcus aureus (MRSA) isolates and 12 methicillin-resistant Staphylococcus epidermidis (MRSE) isolates moder ately resistant to sparfloxacin. Synergic interactions were observed m ore frequently against MRSE than against MRSA strains. The most effect ive combination on both species was fosfomycin plus oxacillin, synergi stic against ten of 16 MRSA and eight of 12 MRSE strains.